- rajputbhagatsingh@gmail.com
- 2, Rupa Adarsh Soc., Saraswati Lane, Santacruz (W), Mumbai.
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India has a grooming and vibrant regenerative Bone Marrow Derived cell therapy community, built on an approach that involves expert doctors & basic researchers working together to support the emerging demands for this specialization.
2, Rupa Adarsh Soc., Saraswati Lane, Santacruz (W), Mumbai.
Lou Gehrig's disease, otherwise known as amyotrophic lateral sclerosis (ALS), is a grave neurodegenerative condition that assaults the motor neurons located in the brain and spinal cord, leading to impairment of the muscles throughout the body. The disorder's literal definition pertains to the degeneration of voluntary muscles caused by an insufficient supply of nutrients.
In two to five years, the person will become paralysed and die as their muscles deteriorate. Lower motor nerve cells, which regulate a variety of functions including limb movement, swallowing, and even breathing, are the only neurons impacted.
There isn't a clinically useful treatment for ALS at the moment. The use of medications with anti-inflammatory, and anti-apoptotic qualities, pharmaceuticals that provide trophic factors, as well as glutamate receptor blockers have all been tried as therapy approaches in the past, but none of them have produced conclusive outcomes in clinical trials.
Only one drug, Riluzole, has been licenced by the Food and Drug Administration (FDA) for the treatment of ALS. This anti-glutamate medication has an uncertain mechanism of action and only slightly lengthens patients' lives by two to three months. ALS patients are still in dire need of new medications because there is no effective treatment for the disease.
The most thorough method of treating ALS would be to create a therapy that can sustain or regain motor neuron activity, given the intricacy of the illness and the least understood pathomechanisms.
The earliest symptoms are typically so modest that they might occasionally be disregarded. Some of these include slurred or nasal speech, fasciculation, cramping, tight muscles, and trouble chewing or ingesting. These initial signs and symptoms could worsen into significant atrophy, leading a doctor to suspect ALS. Other than the first signs, the upper motor neuron's increasing symptoms include spasticity and heightened reflexes, such as the huge toe pointing upward when the foot's sole is stimulated in a particular way.
The process that is followed is that a certain number of stem cells are isolated from either of the sources- autologous i.e. from the body of the patient or allogeneically using the help of a donor. These stem cells are then isolated and enriched to be infused back into the body of the patient. This can be via an intrathecal or intravenous administration. Post infusion, these cells improve the voluntary functions of the body.
This therapy is being researched as a possible treatment for Amyotrophic Lateral Sclerosis (ALS) . Stem cells are able to acquire new specialized characteristics by being induced in a lab through differentiation and/or trans-differentiation. These processes may allow stem cells to develop new properties, including supporting and encouraging neuroprotective qualities within damaged tissue, helping repair and potentially delay the breakdown of motor neurons while also facilitating axonal growth.
Owing to its regenerative ability, stem cells are used for the treatment of a wide range of ailments, including amyotrophic lateral sclerosis (ALS). However, if we specifically talk about the effect of stem cell therapy in ALS, various clinical models suggest that mesenchymal stem cells (MSCs) may represent a promising approach to treat ALS. Well, mesenchymal stem cells have been used to treat certain diseases and disorders, such as heart attacks, osteoarthritis, nerve damage, eye injuries, and even corneal blindness. One of the most critical functions that they carry out is assisting in tissue healing and regeneration by releasing growth factors. They have also been used to fight cancer tumors by either identifying which type of tumor the patient has and then adapting directly to those properties through differentiation or directly attacking cancerous tumors through the immune response.
Nonetheless, reaching out to a reliable therapy canter can be a complex task, but you don’t have to worry as long as Dr. Rajput is with you. He is the founder of Stem Cell Research Center where you can go to get top-class stem cell therapy at the most reasonable costs.
Stem Cell treatment for ALS is available in India and the average cost is estimated to be between 15-25 lacs depending upon the kind of facilities the patient opts to avail during treatment.
The prevalence rate of ALS has been estimated to be 3.9 per 100,000 patients on average. With an increase in the total number of reported cases, this ratio rises each year.
The cells derived from the blood of the human umbilical cord, embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells and neural stem cells can be used for the treatment of ALS.
The enriched stem cells are infused back into the body of the patient, and this can be via an intrathecal or intravenous administration.
