Stem Cell Therapy for Limb Girdle Muscular Dystrophy

Stem Cell Therapy for Limb Girdle Muscular Dystrophy

Limb-Girdle Muscular Dystrophies (LGMD) are a group of muscular dystrophies, that until the late 1980s were identified in patients by ‘diagnosis by exclusion’. Revolutionary advances in molecular biology in the last several decades have allowed the scientific community to understand and recognize this disease more clearly. Currently, there are >25 LGMD types that have been linked to specific gene loci, and they are now estimated to constitute one third of all Duchenne muscular dystrophy cases.

Limb-Girdle Muscular Dystrophy is a term for a group of diseases that cause weakness and loss of the muscle mass in the legs and arms. The severity, age of onset, and functions of limb-girdle muscle dystrophy vary most of the subtypes of this condition and can be inconsistent even within the identical family. Symptoms and signs may also first appear at any age and usually get worse with time, even though in some cases they continue to be moderate. In the early stages of limb-girdle muscular dystrophy, affected people may additionally have an unusual walking gait, including waddling or walking at the balls in their feet, and can also have a problem in running. they may want to use their arms to press themselves up from a squatting position due to their vulnerable thigh muscle mass. because the circumstance progresses, humans with limb-girdle muscular dystrophy may sooner or later require wheelchair assistance.


Stem Cell Therapy for Limb Girdle Muscular Dystrophy
Scientists have proved that our body has distinct sources of stem cells in different organs which aren't being used by them. These sources of stem cells can now be exploited to isolate rich population of stem cells which when infused into the muscles can replace the damaged muscle cells with wholesome muscular fibres and decreased the inflammation related to the muscular dystrophy thereby slowing the development of the disease.