Muscular Dystrophy Treatment In India
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disease. Worldwide, around 1 in 3500 boys suffer from DMD. The child is usually normal at birth but the disease onsets around 3 years of age.
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disease. Worldwide, around 1 in 3500 boys suffer from DMD. The child is usually normal at birth but the disease onsets around 3 years of age. Initially, the child starts feeling difficulty in getting up from the ground which is accompanied by frequent falling on brisk walking. Gradually, the problem going on increasing in the form of calf muscle enlargement with inability to climb the staircase. In the following time, all the muscles of the body starts to lose power and the child is bed-ridden between the age of 8-10 years. In most cases, death occurs between 14 to 21 years due to respiratory or cardiac failure. DMD results due to deficiency of a protein called dystrophin in the muscle cells.
Dystrophin is an integral part of skeletal and cardiac muscles and plays paramount role in the structural stability of these muscle fibres. Therefore, when dystrophin is absent in DMD boys, they exhibit gradual muscle weakness in all the muscles of the body. The standard mode of treatment is corticosteroids such as prednisone or Deflazacort. However, use of corticosteroids will merely delay the manifestation of the disease. Moreover, these steroids are associated with side effects such as fatigue, nausea, headache and vomiting. Patients are also recommended physiotherapy that aids in muscle flexibility in the early stages of disease but is incapable of reversing the disease modality. At Dr. Rajput’s orthopaedic and stem cell transplant centre, the younger patients are advised to take tablet Modunol to maintain their muscular strength and avoid the use of corticosteroids.
We at Dr. Rajput Stem Cell Research Centre also offer a stem cell therapy for DMD patients and have found remarkable outcomes. In the treatment, we transplant as well as transfuse the patient with cord blood mesenchymal stem cells, which contains dystrophin protein. Owing to the multilineage property of mesenchymal stem cells, it readily gets engrafted in the damaged muscles and works to repair the muscle. Through meticulous condition monitoring of all our patients, we have constantly observed that the treatment halts the progression of the disease. Thus, does not allow the patient to get trapped in the deadly scenario of being bed-ridden/cardio-repiratory failure, which invariably leads to untimely demise of these children.
Noticeable upturn is observed in the muscle flexibility of the patient within four months of stem cell treatment. In our series of stem cell transplantation, in about 50 patients treated in last 5 years, we have observed that, they are maintaining their muscle power. We further observed that none of our patients died in the follow-up of last five years. In our protocol, we gave booster sessions of stem cell transplantation on yearly bases. Thus, our protocol of stem cell therapy in India has revolutionised the earlier followed treatment pattern for DMD. We can now say that, with the advent of this innovative stem cell therapy in India, treatment of DMD has become possible. Testimonials of the patients treated for DMD can be seen in the testimonial section of this website.
Muscular Dystrophy DMD is diagnosed in most children when they’re about 3-5 years old and when it becomes apparent that their physical abilities are not in sync with the normal course of development.
Symptoms of DMD can easily be detected during a physical exam.
For a more thorough test, blood samples can be analyzed to check levels of creatine kinase (CK), an enzyme that leaks out of damaged muscle, indicating that the muscle tissue is being destroyed.
Genetic testing can confirm the diagnosis in many cases of MD. However, MD has many different forms, so if your child does not have one of the more common types, a muscle biopsy may be needed.
Muscle biopsy, which constitutes taking a small sample of muscle tissue and its examination under a microscope. This may be important as the diagnostic tool for less common MDs.
Electrocardiogram (ECG or EKG), a test that records the electrical activity of the heart, shows arrhythmias or dysrhythmias (abnormal rhythms) and detects any damage to the heart muscle.
There is no current cure for DMD. The treatment is aimed at controlling the inception of symptoms to maximize the quality of life, and include the following: Corticosteroids increase energy and strength and defer severity of some symptoms.
Mild, non-jarring physical activity such as swimming is encouraged. Inactivity (such as bed rest) can deteriorate the health.
Physical therapy to maintain muscle strength, flexibility and function is encouraged.
Appropriate respiratory support as it is a progressive disease.
Surgical remedies can loosen joints drawn inward by contractors.
Not responding well to conventional therapy? May be we can help. Write to us at
Stem Cell Treatment
There is no current cure for DMD. The treatment is aimed at controlling the inception of symptoms to maximize the quality of life, and include the following:
Stem Cell India Research Centre can offer you stem cell therapy using our proprietary technology.
These stem cells could be of various types viz. Hematopoietic (CD 34+), Mesenchymal stem cells (MSCs) that are processed and isolated using Good Manufacturing (GMP) and Good Lab Practices (GLP) and in accordance with AABB standards.
This novel therapy is based on a natural human protein that can significantly slow the muscle damage and improve its functions.
We are confident that using stem cell therapy, we can help the patient not only to reverse the disease process of the affected body part but also improve the overall quality of life.
Stem cells produced by Stem Cell India Research Centre are completely non-toxic, safe, easy to administer with an excellent probability of homing and engraftment with parent cell, tissue or organ. Our researchers and scientists work exhaustively to design accurate treatment protocols that have the capability to yield excellent results.
Depending upon the requirement on the patient, the stem cells can be procured from bone marrow or cord blood fat.
Stem Cell India Research Centre advises an early treatment to prevent rapid deterioration of strength in muscles. The stem cell therapy also helps avoid patient’s dependence on support for walking & other activities.